Alzheimer’s disease and CBD meet at the endocannabinoid system.
There is hardly any condition as debilitating as Alzheimer’s disease and CBD may slow its progression. According to the Alzheimer’s Disease Association, Alzheimer’s disease accounts for over 60% of all cases of dementia. Furthermore, more than 33 million people across the globe suffer from this crippling condition. Patients with Alzheimer’s disease experience various stages of memory loss. Ultimately, those inflicted lose speech and cognitive motor skills . Sadly by this time, they have lost all memory and recognition of loved ones.
Scientists believe beta-amyloid protein production and tau phosphorylation contribute to Alzheimer’s disease, and CBD regulates both.
Scientists believe that the development of plaques and tangles in the brain causes Alzheimer’s disease. The plaque is a buildup of a protein known as beta-amyloid. A process of phosphorylation to another protein called tau causes the tangles. Ironically, tau is actually present to keep pathways between synapses and neurotransmitters straight. Once areas around nerve cells become clogged by plaque, however, the tau gets tangled up. Further phosphorylation takes places during waves of neuro-inflammation. Inevitably, neurological damage ensues.
The International Journal of Molecular Science published a study regarding Alzheimer’s disease and CBD. Scientists discovered that CBD actively inhibits the production of the beta-amyloid protein. Furthermore, CBD works to regulate the protein involved in the phosphorylation process of tau. (http://www.mdpi.com/1422-0067/18/1/26)
CBD helps regulate microglial activity that increases neurological damage during of inflammation.
The Department of Pharmacology in the University of Washington, in Seattle, WA, also conducted research. In this study, scientists learned of the relationship between CBD and microglial cells. Scientists recognize that dying neutrons tend to attract microglial cells. These cells increase the neurological damage taking place during waves of neuro-inflammation. CBD activated certain receptors that minimized the production and regulated the activity of these ‘anarchists’. (https://www.ncbi.nlm.nih.gov/pubmed/12598628)
Memory loss is a characteristic of Alzheimer’s disease, and CBD helped to improve memory function while allowing all social functionality to remain intact.
The Journal of Alzheimer’s Disease published a study on Alzheimer’s disease and CBD. In this study, mice were treated with CBD. Mice who received CBD treatments displayed improved memory function. CBD had no negative impact on social learning or cognitive abilities. (https://www.researchgate.net/publication/263934508_Long-Term_Cannabidiol_Treatment_Prevents_the_Development_of_Social_Recognition_Memory_Deficits_in_Alzheimer’s_Disease_Transgenic_Mice)
Studies with Alzheimer’s disease and CBD may redefine future treatments.
Over the course of time, significant neurological damage occurs with Alzheimer’s disease and CBD reduces production and activity of each known factor. Notwithstanding, there are still elements of Alzheimer’s disease that are highly unknown. However, as scientists learn more about Alzheimer’s disease and CBD, prevention may become more relevant than the cause.