CBD for Huntington’s Disease
Scientists believe CBD for Huntington’s disease may help slow its progression. Notwithstanding, laboratories still need to conduct more research. There are plenty of initial lab reports indicating that CBD plays a huge role in managing neurodegenerative disorders like Huntington’s disease and Parkinson’s disease.
Medical professionals believe Huntington’s disease is inherited. Scientists also know that patients with Huntington’s disease have a higher rate CAG sequence repitition. A series of CAG (cytosine, adenine, and guanine) repeats are normal in a DNA sequence. Within a normal gene, there may be 10-35 CAG repeats. However, patients with Huntington’s disease have DNA with a much higher CAG repeat. This causes an expansion of a protein constituent known as polyQ (polyglutamine). As a result, this heightened level of activity causes significant damage in the striatal and cortical neurons. Consequently, patients suffer from a loss of motor skills and dementia. (https://www.ncbi.nlm.nih.gov/pubmed/22280340)
In short, CBD for Huntington’s disease is effective because of its neuroprotective and anti-inflammatory properties. Like many diseases CBD helps, understanding the manner in which it helps to slow the progression of Huntington’s disease requires an understanding of the activity that takes place in the endocannabinoid system when living beings ingest CBD. Here, we will look at a variety of studies concerning CBD and Huntington’s disease.
Cannabis-based medicine Sativex was studied for its neuroprotective properties as a CBD treatment for Huntington’s disease.
Scientists in Spain used Sativex as an agent to test the efficacy of CBD for Huntington’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/21674569) They discovered that CBD helped to regulate GABA production. Medical professionals associate GABA deficiency very closely with Huntington’s disease.
Other factors that contribute to neurological damage associated with Huntington’s disease include cysteine protease activity in a group of proteases known as calpains. CBD helped to regulate calpain expression while increasing IGF-1 (Insulin-like growth factor) production. IGF-1 is a hormone that promotes healthy neurological activity. While this hormone occurs naturally in our body, its production is increased when CBD is consumed.
Preliminary studies on CBD for Huntington’s disease indicate that more research is warranted.
The National Center for Biotechnology Information published a report citing a variety of initial lab reports concerning the benefit of CBD for Huntington’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/28412918) These findings suggest that CBD produces a variety of enzymes, hormones, and proteins through the endocannabinoid system that can significantly slow the progression of Huntington’s disease. Additionally, this report concludes that CBD is also an effective treatment for a variety of other neurodegenerative diseases.