Research on CBD oil for Parkinson’s disease shows promise. According to Parkinson’s Foundation, Parkinson’s disease affects at least one million people in the United States. Worldwide, experts estimate that around ten million people have PD.
What is PD and how is CBD oil for Parkinson’s disease effective?
First, let’s identify what Parkinson’s disease is. Parkinson’s disease is a neurodegenerative disorder. More specifically, it is a disorder that affect the substantia nigra region of the basal ganglia in the brain. The substantia nigra is the area in which the brain produces dopamine-producing neurons. Medical experts refer to these neurons as ‘dopaminergic’. Like other neurodegenerative diseases, oxidative stress that occurs to neurotransmitters and pathways results in neurological cell death, thus causing the debilitating symptoms of PD to progress.
Parkinson’s disease causes production of these dopaminergic neurons to be interrupted. The result is the onset of debilitating symptoms. Symptoms develop at different rates in different patients, but it’s generally a gradual process over time. Early symptoms include a slower gate, walk, or movement; constipation; dizziness or fainting; difficulty moving, having trouble standing up straight, hunching over; loss of smell; tremors; trouble sleeping; smaller handwriting; and one’s voice at a lower volume than normal.
Ultimately, three of the most defining characteristics of Parkinson’s disease include bradykinesia (slowed movements), rigidity of limbs, and tremors. Furthermore, patients with advanced PD also have problems with balance and gait. Unfortunately, psychosis is also a symptom of advanced Parkinson’s disease.
So how can CBD oil for Parkinson’s disease help?
Like CBD oil for Huntington’s disease and other neurological disorders, CBD oil for Parkinson’s disease works in a variety of ways. We will look more specifically at the different ways in which CBD therapy treats PD as we look at each study related to treating Parkinson’s disease with cannabinoids. For now, though, we will surmise to say: CBD stimulates enzymes and neurotransmitters that regulate activity in the basal ganglia. The positive influence of CBD on the endocannabinoid system results in the brain producing dopaminergic neurons more consistently for the duration of treatment. As such, the development of Parkinson’s disease can be arrested.
Furthermore, CBD oil for Parkinson’s disease helps to prevent cell death caused by oxidative stress. Not only that, cannabinoids have neuro-protective properties that keep neuro-pathways in optimal condition, free of inflammation.
Scientists proved that CBD helped to significantly increase the quality of life of those living with Parkinson’s disease.
A group of neuroscientists in Brazil conducted a double-blind trial related to CBD oil for Parkinson’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/25237116)
In this study, they reported that the levels of CBD they used did not significantly impact motor and general symptoms scores. However, patients who were taking CBD for PD symptoms had much higher quality of life scores than those taking a placebo.
Endocannabinoid professionals now know that CBD oil for Parkinson’s disease works to reduce 6-hydroxydopamine toxicity in the basal ganglia, thus providing advanced neuroprotection.
A group of biological scientists in Spain conducted a study related to CBD oil for Parkinson’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/15837565)
In this study, they learned that cannabinoids helped to reduce toxicity levels and subsequent neurological damage caused by 6-hydroxydopamine. They stated that these findings were relevant to Parkinson’s disease. Furthermore, this knowledge could be used as a rationale to conduct more research on treating symptoms of Parkinson’s disease with cannabinoids.
Research shows that CBD oil for Parkinson’s disease helps to manage sleep by relieving symptoms of RBD (REM sleep behavior disorder).
Neuroscientists in Brazil conducted a study related to CBD oil for Parkinson’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/?term=Cannabidiol+can+improve+complex+sleep-related+behaviours+associated+with+rapid+eye+movement+sleep+behaviour+disorder+in+Parkinson%27s+disease+patients%3A+a+case+series)
More specifically, they were seeking to treat a specific symptom of Parkinson’s disease. REM sleep behavior disorder is a condition that results in nightmares and interrupted sleep patterns. It is caused by rigidity of muscles. As a matter of fact, they are unable to relax and achieve an atonic state during a normal REM cycle. Researchers reported a “prompt and substantial reduction in the frequency of RBD-related events without side effects.”
Research on CBD oil for Parkinson’s disease shows that CBD not only prevents neuro-inflammation, but also protects against oxidative stress.
A group of neuroscientists in United Arab Emirates conducted a study on CBD oil for Parkinson’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/27531971)
In this study, medical experts targeted the CB2 receptor. They reported that CBD therapy prevented neuro-inflammation. Furthermore, it helped to reduce the effects of oxidative stress, thus preventing long-term damage and slowing the progression of PD.
CBD oil for Parkinson’s disease also has the potential to manage symptoms of psychosis.
A group of psychiatric researchers in Brazil conducted a study related to CBD oil for Parkinson’s-related psychosis. (https://www.ncbi.nlm.nih.gov/pubmed/18801821)
In this study, they identified that CBD therapy reduced the presence of psychotic symptoms without any negative side effects.
A list of other endocannabinoid professionals and scientists from around the world recognize the potential of CBD oil for Parkinson’s diseases.
A group of researchers in the United States shared information on the therapeutic value of cannabinoids in a variety of diseases having to do with the central nervous system. (https://www.ncbi.nlm.nih.gov/pubmed/12617697)
A group of professionals in Spain produced similar literature. (https://www.ncbi.nlm.nih.gov/pubmed/21545415). Here, though, they focused more specifically on CBD for basal ganglia disorders. They made a specific mention of both Parkinson’s disease and Huntington’s disease.
Finally, researchers in Italy also compiled a list of resources for review and submitted literature related to the benefit of CBD oil for Parkinson’s disease. (https://www.ncbi.nlm.nih.gov/pubmed/28412918)
Conclusion on CBD oil for Parkinson’s disease
While medical experts say that Parkinson’s disease, itself, is not fatal, the Center for Disease Control and Prevention lists Parkinson’s disease among the leading causes of death in the United States. More research on CBD and PD may make more novel treatments available. Fortunately, it’s easy to get the best CBD oil for Parkinson’s disease symptoms with high quality, full spectrum options.